Nottingham Prognostic Index Calculator

Calculate the Nottingham Prognostic Index (NPI) to predict survival outcomes in breast cancer patients.

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Input Parameters

Enter details for calculation.

Nottingham Index

4.50
Moderate prognosis (15-yr survival ~50%)
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Expert Tip

An NPI score < 2.4 indicates excellent prognosis, while an NPI > 5.4 correlates with poor long-term survival.

Calculation Methodology & Details

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Formula

NPI = (0.2 × Size) + Node_Score + Grade_Score

Established mathematical index evaluating tumor diameter, pathological lymph node metastasis, and grade.

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Important Disclaimer

The calculations provided are for educational and general informational purposes only. They do not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider.

How NPI is Scored

Follow these steps to use this calculator:

1

Enter Tumor Size

Input largest diameter of primary lesion in centimeters.

2

Choose Node and Grade

Input pathological lymph node involvement and tumor differentiation grade.

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Detailed Insights & Expert Guide

ℹ️ About this Calculation

This clinical oncology calculator provides chemotherapy dosing precision, tumor staging risk stratification, performance status scoring, and prognostic index evaluation based on ASCO and NCCN clinical guidelines.

Variable Glossary

Input

Oncology & Lab Data

Serum creatinine/eGFR, target AUC, GFR (Calvert formula), BSA (m²), tumor size/grade, or biopsy scores.

Parameter

Prognostic Index

Calculated dose (mg), ECOG grade (0-5), Nottingham Index score, or 10-year cancer risk percentage.

How to Calculate Step-by-Step

1

Step 1

Enter patient body surface area, GFR/creatinine clearance, or histopathological biopsy findings.

2

Step 2

Specify target AUC dose parameters or patient functional performance status options.

3

Step 3

Review calculated chemotherapy total mg dose, risk stratification category, or survival probability estimates.

FAQ

How is Carboplatin dose calculated using the Calvert formula?
The Calvert formula calculates Total Dose (mg) = Target AUC × (GFR + 25), where GFR is typically estimated using Cockcroft-Gault creatinine clearance capped at 125 mL/min.
What is the difference between ECOG and Karnofsky performance status?
ECOG ranges from 0 (fully active) to 5 (deceased), providing a 6-point scale. Karnofsky runs from 100% to 0% in 10-point increments. Both measure patient functional capacity in oncology clinical trials.
Can oncology calculators replace multidisciplinary tumor board review?
No. Chemotherapy dosing and oncologic risk modeling serve as clinical decision support. All treatment protocols require verification by a board-certified medical oncologist.